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KMID : 0359920070260050548
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Korean Journal of Nephrology
2007 Volume.26 No. 5 p.548 ~ p.553
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Nephron Numbers in Patients with Minimal Change Nephrotic Syndrome (MCNS) and Focal Segmental Glomerulosclerosis (FSGS)
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Hwang Hyun Hee
Yun Bong-Sic
Kim Ki-Hyuk
Shin Sug-Kyun
Kang Ea-Wha
Yoo Tae-Hyun
Kie Jeong-Hae
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Abstract
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Purpose : It has been proposed that a decreased nephron number may be associated with the increased risk of glomerulosclerosis. In order to test the hypothesis that a reduced number and an increased volume of glomeruli may contribute to the pathogenesis of focal segmental glomerulosclerosis (FSGS), we compared the number and volume of glomeruli between 9 patients with FSGS and 8 with minimal change nephrotic syndrome (MCNS).
Methods : Mean glomerular volume was measured using the method of Weibel and Gomez. An estimate of glomerular number (index) was obtained by multiplying the cortical volume of a kidney by the fraction of renal cortex made up of glomeruli and dividing this by the mean glomerular volume for that kidney×106. We determined kidney volume from ultrasonographic measurement.
Results : Patients with FSGS had significantly greater glomerular volume than patients with MCNS [2.02±0.36 (×106 μm3) vs. 1.57±0.27 (×106 μm3)] (p<0.025). However, there was no significant difference in the index of glomerular number (estimated glomerular number) between FSGS & MCNS patients (2.8±1.4 vs. 3.0±0.8).
Conclusion : The glomerular volume was greater in FSGS patients than MCNS patients. But there was no significant difference in the index of glomerular number between patients with FSGS and MCNS.
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KEYWORD
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Kidney glomerulus, Nephrotic syndrome, Minimal change, Focal segmental glomerulosclerosis
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